Colon cells are exposed to constant environmental assault ranging from natural toxins to pesticides to heterocylic amines produced by cooking food, especially meats at high temperatures. Colon PF activates the body's defense mechanisms, including Phase 2 detoxification enzymes. It also supplies compounds that combat the effects of heterocyclic amines and modulate colon cell cyclooxygenase-2 responses to environmental challenges. Colon PF contain a combination of the most powerful cell protectants found in the fruit and vegetable worlds and traditionally associated with good intestinal health, including curcumin, lycopene from concentrates, milk thistle extract, PomGuard pomegranate extract and hesperidin, methylchalcone.