Numerous scientific studies show glucosamine sulfate to be highly effective. An advancement over competitive brands, FlexMax is non-irritating to the stomach because of its proprietary StomachGuard technology that utilizes plant fibers to form a protective gel around the tablet upon entering the digestive tract. This natural gel provides a cushioning effect and regulates the release of glucosamine, thus shielding against potential stomach irritation. Nature's Way FlexMax can be comfortably taken at any time of the day, with or without a meal.